Physician researchers from the University of Maryland Department of Orthopaedics are involved in more than 17 orthopaedic clinical trials and grants totaling $45 million. The Department currently ranks 4th by Blue Ridge Institute for Medical Research in funding for orthopaedic departments of public medical schools.

Read below for details about our clinical studies and grants.

Research Grants and Awards

Negative Pressure Wound Therapy vs. Bead Pouch for Traumatic Wounds

Gerard Slobogean, MD, MPH, and his research colleagues at the UM SOM Department of Orthopaedics received a $2.5M Department of Defense award from the Congressionally Directed Medical Research Programs (CDMRP) and Peer Reviewed Orthopaedic Research Program (PRORP) to study negative pressure wound therapy versus bead pouch for management of severe traumatic wounds. This work has tremendous potential to provide critically important information that will allow better treatment of wounded warriors and civilians alike.

Veteran’s Administration Career Development Award


Natalie L. Leong, MD, associate professor of orthopaedics, was awarded this career development award to support her efforts to study the role of peri vascular stem cells in ligament and tendon healing.

Historic Orthopaedic Trauma Trials Setting Worldwide Practice Standards

University of Maryland’s orthopaedic team leads the two largest orthopaedic trauma trials ever conducted. The study results are due for release in late 2022 and provide high-quality evidence to surgical practices worldwide.

PREVENT CLOT - $12 million in funding from the Patient-Centered Outcome Research Institute to compare the use of low-molecular-weight heparin (enoxaparin) versus aspirin to prevent fatal pulmonary embolism in trauma patients. The trial recently completed the enrollment of 12,200 from 21 trauma centers in the US and Canada.

PREP-IT - $15 million grant evaluating two pre-operative antiseptic skin preparation methods to prevent surgical site infections and unplanned fracture-related reoperations.

  • A-PREP evaluates if aqueous pre-operative antiseptic skin preparation with 10% povidone-iodine is more effective than 4% chlorhexidine in patients with open fractures.
  • PREPARE evaluates if alcohol-based pre-operative antiseptic skin preparation with iodine-povacrylex (0.7% free iodine) is more effective than 2% chlorhexidine gluconate in patients with open and closed lower extremity and pelvic fractures.

OREF Soft Tissue Repair and Regeneration Sports Medicine Grant In Honor of Russell F. Warren, MD


Natalie L. Leong, MD is the principal investigator for the research award “Therapeutic Application of Perivascular Stem Cells to Rotator Cuff Repair”. Grant funds are raised by the Orthopaedic Research and Education Foundation (OREF).

Center for Orthopaedic Injury Research & Innovation

In early 2022, the department will launch the Center for Orthopaedic Injury Research & Innovation (COIRI). Led by Gerard Slobogean, MD, and Nathan O’Hara, PhD, COIRI aims to expand the research methods expertise of the orthopaedic fracture surgery community, develop new research ideas capable of improving clinical outcomes, and implement rigorous research methods for orthopaedic fracture surgery studies.

Mortality in Hip Fracture Patients: Identifying the Prognostic Value of Troponin

In conjunction with collaborators at McMaster University, the University of Maryland’s orthopaedic team is initiating a 1,100-patient international, multicenter randomized controlled trial (HIP-ATTACK 2) to compare accelerated surgery to standard care in hip fracture patients presenting with elevated troponin levels. Trial findings will generate more evidence to help evaluate the benefits of accelerated surgical care for hip fracture patients and have the potential to significantly change the paradigm of postponing hip fracture surgery in patients with evidence of acute heart injury.

Intrawound Vancomycin Powder to Reduce Surgical Site Infections

In collaboration with the Major Extremity Trauma Research Consortium, Robert O’Toole, MD, and members of the University of Maryland Department of Orthopaedics recently published a 980-patient randomized trial in JAMA Surgery on the effect of intrawound vancomycin powder in preventing infections in high-risk tibial plateau and pilon fractures. The results offered strong evidence that vancomycin powder placed in the surgical wound at the initial fracture treatment is a promising, low-cost intervention to reduce the risk of gram-positive post-operative infections.

To refer a patient to a University of Maryland Orthopaedics specialist, call 410-448-6400. To schedule a grand rounds presentation with our physicians, contact Diane Fisher at

Will you be at AAOS 2022 in Chicago? If so, we invite you to attend more than 25 presentations and papers given by our physician research team. View the full schedule