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The University of Maryland Medical Center (UMMC) is the flagship academic medical center at the heart of UMMS and includes the 789-bed downtown Baltimore campus and the 177-bed midtown campus one mile north. The medical staff comprises nearly 1,200 attending physicians who are faculty members at the University of Maryland School of Medicine, as well as 900 residents and fellows in all medical specialties. 

UMMC is home to the Marlene and Stewart Greenebaum Comprehensive Cancer Center and The R Adams Cowley Shock Trauma Center, the highest-volume trauma center in the United States.

UMMC was established in 1823 in partnership with the first public medical school in the nation. Today, as then, all attending physicians at UMMC are faculty members at the University of Maryland School of Medicine.