A subject takes part in a multiple sclerosis clinical trial

Opportunities are available for individuals with Multiple Sclerosis to participate in several new clinical trials at the University of Maryland Center for Multiple Sclerosis Treatment and Research.

These studies are either currently enrolling or will be enrolling shortly.

The studies vary in design, duration, criteria for eligibility, number of MRI scans and other details. The following is a very brief summary of each study. You may obtain further information by calling Kerry Naunton, R.N., 410-328-5605 at the MS Center.

Clinical trial opportunities are constantly changing. Please keep in touch if you are interested in trials.

Current Clinical Trials

High field MRI for visualization of cortical pathology, meningeal inflammation, and neurodegeneration in multiple sclerosis

  • Application No: HP-00079860
  • Principal Investigator: Daniel Harrison
  • For more information please contact Daniel Harrison at 410-328-4682 or dharrison@som.umaryland.edu

 This research is investigating the use of high-field (7-tesla) MRI in visualizing multiple sclerosis-related damage to the gray matter of the brain, degeneration of nerves, and inflammation in the protective tissues around the brain.

Volunteers should be age 18 – 65 and have a diagnosis of multiple sclerosis. A cohort of healthy volunteers (without MS), ages 18 – 65 are also invited to participate. A cohort of participants with other inflammatory conditions of the central nervous system (such as neurosarcoidosis, neuromyelitis optica, autoimmune encephalitis, CNS vasculitis) are also invited to participate.

Participants in the MS cohort will undergo MRIs of the brain, OCT scans, bloodwork and disability and cognitive testing.

Participants in the healthy volunteer and other inflammatory condition cohorts will undergo MRIs of the brain, bloodwork, and disability and cognitive testing.


North American Registry for Care and Research in Multiple Sclerosis (NARCRMS)

  • Application No: HP-00079149

NARCRMS is a database intended to collect longitudinal physician-reported and clinical information from people with multiple sclerosis (MS) over a long period of time and will bring together information and data collected in multiple registries and databases across the U.S. and Canada. We expect that these data, when carefully studied, will be able to:

  1. Produce new clues to the causes of MS
  2. Significantly enhance the ability of physicians, other clinicians and patients to manage symptoms of MS; and
  3. Potentially affect the progression of the disorder, and perhaps lead to the eventual reduction or eradication of MS.

Subjects are invited to participate in this research study because they have MS.  Following your course of MS will help us to better understand this disease in its entirety.

This study will last over 5 years and will include at least 1,000 participants from 20 MS Centers across the U.S. and Canada.

To take part in this study you must be between 18 and 65 years old, been diagnosed with multiple sclerosis and be willing to contribute data on an on-going basis.

Participants in this study will have an annual visit which will include collection of your multiple sclerosis history, a detailed neurologic exam and a brief battery of tests of memory and attention.


Pilot study of meningeal inflammation on 7T MRI as a tool for measuring and predicting ocrelizumab response in multiple sclerosis

Learn more about this study: NCT03396822


Adaptive Optics Retinal Imaging in Multiple Sclerosis

Adaptive Optics Retinal Imaging in Multiple Sclerosis

This research is investigating the use of adaptive optics (AO) retinal imaging to assess how the eye is involved and affected by multiple sclerosis (MS). We are searching for healthy volunteers without MS. Volunteers should be age 21 or older and have no history of MS or eye disease

You will undergo an initial eye exam and then a retinal imaging session. You will be reimbursed for your time as well as any associated parking expenses.

Recognized as a center for comprehensive care by the National Multiple Sclerosis Society
UMMC is a member of the Consortium of Multiple Sclerosis Centers