Dr. David Benavides, left, with a research associate

David Benavides, MD, PhD, left, in the lab with Yuyoung Joo, PhD, a postdoctoral fellow alum.

We are a translational clinical neuroscience research program that investigates immune regulation of neuronal function, with particular interest in autoantibody-mediated neurological syndromes.

We utilize cell culture, primary neuronal culture, and rodent animal models combined with a multidisciplinary approach involving pharmacology, protein biochemistry, proteomics, cell biology, and molecular biology.

The unifying objective of our research is to identify novel therapeutic targets for neurologic diseases.

Dr. Benavides' research focuses on:

  • Immune regulation of neuronal plasticity
  • Neuronal signal transduction
  • Animal models of immune dysregulation

Read Dr. Benavides' publications on PubMed

Techniques Used in the Benavides Laboratory

Green cell markers and red synaptic markers

  • Protein biochemistry
  • Molecular biology
  • Proteomics
  • Pharmacology
  • Live cell microscopy
  • Confocal microscopy
  • Primary neuronal culture
  • Acute rodent brain slice
  • Rodent animal models


The lab actively collaborates with:

Thomas Blanpied, PhD (Physiology)

To use advanced live-cell and super-resolution microscopy to study the effect of immune factors on synaptic structure and function

Joseph Cheer, PhD (Anatomy and Neurobiology)

To investigate cell calcium imaging in vivo

Alexandros Poulopoulos, PhD (Pharmacology)

To establish CRISPR/Cas9 editing of synaptic targets in neurons in vitro and in vivo

Positions Available

Nodes connected by lines

Post-doctoral fellows, PhD students, undergraduate students and technical staff interested in working in our lab are encouraged to contact Dr. Benavides via email.

Contact Us

Benavides Laboratory
University of Maryland School of Medicine
Department of Neurology
Health Sciences Research Facility III
670 W. Baltimore Street
9th Floor – Room 9120
Baltimore, MD 21201