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William F. Regine, MD, FACR, FACRO

  • Professor of Radiation Oncology

William F. Regine, MD, FACR, FACRO


  • Radiation Oncology

  • Cutaneous (Skin) Radiation Oncology

  • Gastrointestinal Radiation Oncology

  • Sarcoma and Connective Tissue Radiation Oncology

About William F. Regine, MD, FACR, FACRO

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Dr. Regine is the Isadore and Fannie Schneider Foxman Chairman and Professor of radiation oncology at the University of Maryland School of Medicine.

Dr. Regine’s areas of interest are gastrointestinal malignancies, particularly pancreatic cancer and central nervous system malignancies, including brain metastases. His practice and research involve treatments such as stereotactic body radiation therapy (SBRT) and Gamma Knife (Radiosurgery).

A graduate of the State University Health and Science School of Medicine in Syracuse, New York, Dr. Regine obtained his training at Thomas Jefferson University Hospital in Philadelphia. He also completed a Radiation Oncology Fellowship in gastrointestinal and head and neck malignancies at Thomas Jefferson University, which included training at the University of Florida.

Dr. Regine is considered a national and international expert in the area of gastrointestinal and central nervous system malignancies, as well as in the use of stereotactic radiosurgery. His first faculty appointment was at St. Jude’s Children’s Cancer Research Hospital where, as a clinical investigator, he helped redefine new standards of care in children with rhabdomyosarcomas. After two years at St. Jude's, he dedicated his career to clinical research in adult cancer patients.

As a principal investigator or co-principal investigator, Dr. Regine participated in at least four national NCI sponsored cooperative group clinical trials. He served as the Principal Investigator/Study Chairman of the U.S. Intergroup/ Radiation Therapy Oncology Group (RTOG) 9704 study evaluating adjuvant therapy in patients with pancreatic cancer, published in the Journal of the American Medical Association (JAMA). This study defined a new standard of care for patients with pancreatic cancer. 

He also served as the Radiation Oncology Principal Investigator/Study Chairman of at least two additional institutional clinical trials published in “Journal of the American Medical Association” and the “Lancet” which defined new standards of care for patients with brain metastases and malignant spinal cord compression. He is co-editor of “Principles and Practices of Stereotactic Radiosurgery,” the first comprehensive textbook of its kind about this treatment. In addition, he is also a member of the GI and Brain Tumor steering committees for the RTOG and is the chairman of the GI section of the National Oral Board examination for trainees in Radiation Oncology. 

Dr. Regine was named a Top Doctor in the specialty of Radiation Oncology by Baltimore magazine and a Super Doctor in the mid-Atlantic by the Washington Post Magazine multiple years. In 2016, he was given the Entrepreneur of the Year Award by the University of Maryland, Baltimore, and in 2018, he was elected President of the University of Maryland Medical Center Medical Staff.

Gender: Male


  • UM Upper Chesapeake Health

  • UM Baltimore Washington Medical Center

  • University of Maryland Medical Center

  • Member of UM Faculty Physicians, Inc.


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University of Maryland Radiation Oncology Associates, PA

22 South Greene Street
Gudelsky Basement
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Baltimore, MD 21201
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Maryland Proton Treatment Center

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Baltimore, MD 21201
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