William F. Regine, MD, FACR, FACRO

  • Isadore and Fannie Schneider Foxman Chair and Professor of Radiation Oncology, Interim President, University of Maryland Faculty Physicians, Inc., Executive Director, Maryland Proton Treatment Center (MPTC)

William F. Regine, MD, FACR, FACRO


  • Radiation Oncology

Available for Telemedicine Visits

About William F. Regine, MD, FACR, FACRO

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Dr. Regine is considered a national and international expert in the area of GI and CNS malignancies, as well as in the use of stereotactic radiosurgery.

His areas of interest include:

  • Gastrointestinal (GI) malignancies including pancreatic cancer
  • Central nervous system (CNS) malignancies including brain metastases
  • Stereotactic body radiation therapy (SBRT)
  • Gamma Knife (radiosurgery)

He is the Isadore and Fannie Schneider Foxman Chairman and Professor of Radiation Oncology at the University of Maryland, ranked top five in the country by the National Institutes of Health (NIH).

A graduate of the State University Health and Science School of Medicine in Syracuse NY, Dr. Regine obtained his training at Thomas Jefferson University Hospital in Philadelphia where he also completed a radiation oncology fellowship in Gastrointestinal and head and neck malignancies (inclusive of training at the University of Florida).

His first faculty appointment was at St. Jude's Children's Cancer Research Hospital where, as a clinical investigator, he helped redefined new standards of care for children with rhabdomyosarcomas. After two years at St. Jude's, he dedicated his career to clinical research in adult cancer patients.

Dr. Regine has served as principal investigator or co-principal investigator in at least four national NCI-sponsored cooperative group clinical trials.

  • He served as the principal investigator/study chairman of the U.S. Intergroup/ NRG Oncology 9704 study, evaluating adjuvant therapy (which aims to lower the risk of cancer returning) in patients with pancreatic cancer. Published in the Journal of the American Medical Association (JAMA), this study defined a new standard of care for patients with pancreatic cancer.
  • He has also been the radiation oncology principal investigator/study chairman of at least two additional Institutional clinical trials published in JAMA and the Lancet, which defined new standards of care for patients with brain metastases and malignant spinal cord compression.

He is co-editor Principles and Practices of Stereotactic Radiosurgery, the first comprehensive textbook of its kind.

In addition, he is also a member of the GI and Brain Tumor steering committees for the NRG Oncology and was the chairman of the GI section of the National Oral Board examination for trainees in radiation oncology.

Dr. Regine was named a "Top Doctor" in the specialty of Radiation Oncology by Baltimore magazine and "Super Doctor" in Mid-Atlantic by Washington Post Magazine for multiple years. In 2016, he was given the Entrepreneur of the Year Award by the University of Maryland Baltimore, and in 2018, he was elected President of the University of Maryland Medical Center Medical Staff Organization.

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Gender: Male

Language(s): English


  • UM Upper Chesapeake Health

  • UM Baltimore Washington Medical Center

  • University of Maryland Medical Center

  • Member of UM Faculty Physicians, Inc.

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