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Central Nervous System Cancer Clinical Trials

Coordinator: Megan Camara | 410-369-5355

NRG BN012 | A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases

Principal Investigator: Mark Mishra, MD

Sites: 

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.

EAF151 | Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

GCC 19140 | Pilot Study of Laser Interstitial Thermal Therapy Followed By Hypofractionated Radiation Therapy For Recurrent Gliomas

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.

GCC 20138 | Laser Interstitial Thermal Therapy Followed By Hypofractionated Radiation Therapy For Treatment of Newly Diagnosed High-Grade Gliomas

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

NRG BN005 | Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

NRG BN009 | Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) For First or Second Distant Brain Relapse After Upfront SRS With Brain Metastasis Velocity ≥4 Brain Metastases/Year

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.

NRG BN011 | A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

NRG CC009 | Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or fewer Brain Metastases from Small Cell Lung Cancer

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.

Head and Neck Cancer Clinical Trials

Coordinator: Kelly Kitzmiller | 410-369-5264 

EA3191 | A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features

Principal Investigator: Matthew Ferris, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial. 

RTOG 1216 | Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Principal Investigator: Matthew Ferris, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial. 

NRG HN009 | Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Principal Investigator: Matthew Ferris, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

Find more head and neck cancer clinical trials at UMGCCC.

Breast Cancer Clinical Trials

Coordinator: Caitlin Eggleston | 410-328-7586

GCC 1570 PCG BRE007 | Phase II protocol of proton therapy for partial breast irradiation in early stage breast cancer

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

GCC 15100 | PRoton vs. PHoton | Pragmatic Phase III Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

Principal Investigator: Mark Mishra, MD

Sites:

  • Maryland Proton Treatment Center
  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.

NRG BR007 | A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER2-Negative, Oncotype Recurrence Score (DEBRA)

Principal Investigator: Sarah McAvoy, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.

A221803 | Mepitel Film for the Reduction of Radiation Dermatitis in Breast Cancer Patients Undergoing Post-Mastectomy Radiation Therapy: A Randomized Phase III Clinical Trial

Principal Investigator: Sarah McAvoy, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.

CCTG MA.39 | Tailor RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive and T3N0 Breast Cancer

Principal Investigator: Sarah McAvoy, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.

GammaPod Studies

GCC 1876 | Tumor Bed Boost using a Breast Specific Radiosurgery Device, The GammaPodTM: Registry Study and Evaluation of Quality of Life with Development of Sizing Nomogram; PI: Nichols

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.

GCC 1926 | A Phase I Dose Escalation Study of Single Fraction Pre-operative Partial Breast S-PBI for Early Stage Breast Cancer

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • University of Maryland Medical Center, Referral from:
    • University of Maryland Baltimore Washington Medical Center
    • University of Maryland Upper Chesapeake Health
    • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

Lung Cancer Clinical Trials

Coordinator: Reuben Van Eck | 410-369-5353

GCC 1635 | Bronchial mapping Investigating Radiation-Induced Injury to Airways and Pulmonary Vasculature in Lung Stereotactic Ablative Body Radiotherapy (SAbR)

Principal Investigator: Amit Sawant, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial. 

RTOG 1308 | PRoton vs. PHoton | Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC

Principal Investigator: Zaker Hamid Rana, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

S1827 | MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Principal Investigator: Matthew Ferris, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.  

NRG LU007 | Randomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial

Principal Investigator: Zaker Hamid Rana, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.

GI Cancer Clinical Trials

Coordinator: Reuben Van Eck | 410-369-5353

NRG GI006 | PRoton vs. PHoton | Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.

GCC 1886 | Phase I Study of Concurrent Nab-Paclitaxel + Gemcitabine with Hypofractionated, Ablative Proton Therapy for Locally Advanced Pancreatic Cancer

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

NRG GI003 | PRoton vs. PHoton | A Phase III Randomized Trial of Protons Versus Photons for Hepatocellular Carcinoma

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

GCC 20122 | Early feasibility study to evaluate the initial safety and device functionality of VectRx Thermal Therapy added to neo-adjuvant treatment of pancreatic tumors

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center

GCC 2242 | Hybrid Virtual MRI/CBCT for Image Guidance in Liver Radiation Therapy

Principal Investigator: Lei Ren, PhD

Sites:

  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center

Genitourinary and Gynecological Cancer Clinical Trials

Coordinator: Caitlin Eggleston | 410-328-7586

GCC 1944 | A Randomized Phase III Trial of Two Standard Dose Fractionation Regimens for Adjuvant Vaginal Brachytherapy in Early Stage Endometrial Cancer

Principal Investigator: Sarah McAvoy, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

GCC 2073 | The "Upproach" Approach: A Phase 2 Study Of Upfront Intensity Modulated Proton Beam Therapy (Impt) And Concurrent Chemotherapy For Post-Operative Treatment In Loco-Regionally Advanced Endometrial Cancer

Principal Investigator: Sarah McAvoy, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

Prostate Cancer Clinical Trials

Coordinator: Acara Carter | 410-369-5350 

GCC 2032 | Phase 1 Feasibility Study of Strength Training with Androgen Deprivation and Proton Therapy for Intermediate and High Risk Prostate Cancer

Principal Investigator: Matthew Ferris, MD

Sites:

  • Maryland Proton Treatment Center

GCC 2048 | A Phase I Dose Escalation Study of Hypofractionated Accelerated Pelvic Nodal Radiotherapy Delivered With A Simultaneously Integrated Prostate Boost For Patients With Localized, Intermediate- And High-Risk Prostate Cancer

Principal Investigator: Mark Mishra, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial. 

GCC 21136 | Phase 2 randomized Total Eradication of metastatic lesions following definitive Radiation to the Prostate in de novo oligometastatic prostate cancer (TERPS) trial

Principal Investigator: Phuoc Tho Tran, MD

Sites:

  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

NRG GU009 | Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (Predict-RT*) *Prostate RNA Expression/Decipher to Individualize Concurrent Therapy with Radiation trial

Principal Investigator: Zaker Hamid Rana, MD

Sites:

  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center
  • Upper Chesapeake Medical Center
  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

NRG GU010 | Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (Guidance)

Principal Investigator: Zaker Hamid Rana, MD

Sites:

  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center
  • Upper Chesapeake Medical Center
  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

EA8191 | Phase III Study of Local or Systemic Therapy Intensification Directed by PET in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence (INDICATE)

Principal Investigator: Mark V. Mishra, MD

Sites:

  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.

Pediatric Cancer Clinical Trials

Coordinator: Caitlin Eggleston | 410-328-7586

GCC 1669 | Pediatric Proton Consortium Registry: Registry for pediatric patients treated with proton RT

Principal Investigator: Young Kwok, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

Other Radiation Oncology Clinical Trials

Contact MPTC Research Office at 410-369-5226

GCC 1552 | PCG Registry | Evaluation Tracking Project: A Prospective Chart Review of Patients Treated with Radiation Therapy

Principal Investigator: Mark Mishra, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

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A high performing hospitals badge from U.S. News & World Report awarded to UM Marlene & Stewart Greenebaum Comprehensive Cancer Center for cancer procedures.
NCI Designated Comprehensive Cancer Center badge
An America's best cancer hospitals badge from Newsweek awarded to UM Marlene & Stewart Greenebaum Comprehensive Cancer Center.