View clinical trials for the following:


Central Nervous System Cancer Clinical Trials

Coordinator: Caitlin Eggleston | 410-328-7586


EAF151 | Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


GCC 19140 | Pilot Study of Laser Interstitial Thermal Therapy Followed By Hypofractionated Radiation Therapy For Recurrent Gliomas

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 20138 | Laser Interstitial Thermal Therapy Followed By Hypofractionated Radiation Therapy For Treatment of Newly Diagnosed High-Grade Gliomas

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG BN005 | Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG BN009 | Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) For First or Second Distant Brain Relapse After Upfront SRS With Brain Metastasis Velocity ≥4 Brain Metastases/Year

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


NRG BN011 | A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.


NRG CC009 | Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for 10 or fewer Brain Metastases from Small Cell Lung Cancer

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.


Head and Neck Cancer Clinical Trials

Coordinator: Kelly Kitzmiller | 410-369-5264


EA3132 | Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


EA3191 | A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features

Principal Investigator: Matthew Witek, MD, MS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG HN005 | A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

Principal Investigator: Matthew Ferris, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


RTOG 1216 | Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Principal Investigator: Matthew Witek, MD, MS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 20110 | A single-arm, single-stage phase II trial of Selective Avoidance of nodal VolumEs at minimal Risk (SAVER) in the contralateral neck of patients with p16-positive oropharynx cancer

Principal Investigator: Matthew Witek, MD, MS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • Maryland Proton Treatment Center
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.


NRG HN009 | Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Principal Investigator: Matthew Witek, MD, MS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.

Find more head and neck cancer clinical trials at UMGCCC.


Breast Cancer Clinical Trials

Coordinator: Sabiha Chowdhuri | 410-328-1681
GammaPod Coordinator: Madiha Qutab | 410-328-6472


GCC 1570 PCG BRE007 | Phase II protocol of proton therapy for partial breast irradiation in early stage breast cancer

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


GCC 15100 | PRoton vs. PHoton | Pragmatic Phase III Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial

Principal Investigator: Mark Mishra, MD

Sites:

  • Maryland Proton Treatment Center
  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.


NRG-BR002 | A Phase IIR/III Trial of Standard of Care Therapy with or without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer

Principal Investigator: Sally Cheston, MD

Sites:

  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.


NRG BR007 | A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER2-Negative, Oncotype Recurrence Score (DEBRA)

Principal Investigator: Sarah McAvoy, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 1618 | Cardiac Magnetic Resonance Imaging and Biomarker Testing For Evaluating Cardiac Injury Resulting From Radiation Therapy In Lung and Breast Cancer: A Pilot Study

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


GammaPod Studies

GCC 1876 | Tumor Bed Boost using a Breast Specific Radiosurgery Device, The GammaPodTM: Registry Study and Evaluation of Quality of Life with Development of Sizing Nomogram; PI: Nichols

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 1926 | A Phase I Dose Escalation Study of Single Fraction Pre-operative Partial Breast S-PBI for Early Stage Breast Cancer

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • University of Maryland Medical Center, Referral from:
    • University of Maryland Baltimore Washington Medical Center
    • University of Maryland Upper Chesapeake Health
    • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.


Lung Cancer Clinical Trials

Coordinator: Madiha Qutab | 410-328-6472


GCC 1635 | Bronchial mapping Investigating Radiation-Induced Injury to Airways and Pulmonary Vasculature in Lung Stereotactic Ablative Body Radiotherapy (SAbR)

Principal Investigator: Amit Sawant, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 1618 | Cardiac Magnetic Resonance Imaging and Biomarker Testing For Evaluating Cardiac Injury Resulting From Radiation Therapy In Lung and Breast Cancer: A Pilot Study

Principal Investigator: Elizabeth Nichols, MD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


RTOG 1308 | PRoton vs. PHoton | Phase III Randomized Trial Comparing Overall Survival After Photon Versus Proton Chemoradiotherapy for Inoperable Stage II-IIIB NSCLC

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.


S1827 | MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

Principal Investigator: Matthew Ferris, MD

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG CC003 | Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Treating Patients With Limited Stage or Extensive Stage Small Cell Lung Cancer

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG LU005 | Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.


NRG LU007 | Randomized Phase II/III Trial of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR Trial

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.


GI Cancer (Esophagus, Pancreas and Liver) Clinical Trials

Coordinator: Ermiece Straub | 410-328-8018


NRG GI006 | PRoton vs. PHoton | Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center

Learn More: Find contact and eligibility information for this clinical trial.


GCC 1886 | Phase I Study of Concurrent Nab-Paclitaxel + Gemcitabine with Hypofractionated, Ablative Proton Therapy for Locally Advanced Pancreatic Cancer

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG GI003 | PRoton vs. PHoton | A Phase III Randomized Trial of Protons Versus Photons for Hepatocellular Carcinoma

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


GCC 20122 | Early feasibility study to evaluate the initial safety and device functionality of VectRx Thermal Therapy added to neo-adjuvant treatment of pancreatic tumors

Principal Investigator: Jason Molitoris, MD, PhD

Sites:

  • University of Maryland Medical Center

Genitourinary and Gynecological Cancer Clinical Trials

Coordinator: Ermiece Straub | 410-328-8018


GCC 1547 | Ultrasound-Based Bladder Scanning for Reproducibility of Bladder-Filling During Abdominopelvic External Beam Radiotherapy

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 1944 | A Randomized Phase III Trial of Two Standard Dose Fractionation Regimens for Adjuvant Vaginal Brachytherapy in Early Stage Endometrial Cancer

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Upper Chesapeake Health
  • Central Maryland Radiation Oncology

Learn More: Find contact and eligibility information for this clinical trial.


GCC 2073 | The "Upproach" Approach: A Phase 2 Study Of Upfront Intensity Modulated Proton Beam Therapy (Impt) And Concurrent Chemotherapy For Post-Operative Treatment In Loco-Regionally Advanced Endometrial Cancer

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


Prostate Cancer Clinical Trials

Coordinator: Grace-Anna Chaney | 410-369-5347


GCC 1547 | Ultrasound-Based Bladder Scanning for Reproducibility of Bladder-Filling During Abdominopelvic External Beam Radiotherapy

Principal Investigator: Pranshu Mohindra, MD, MBBS

Sites:

  • University of Maryland Medical Center
  • University of Maryland Baltimore Washington Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


GCC 1940 | A Prospective Comparative Study of Outcomes with Proton and Photon Radiation in Prostate Cancer (COMPPARE)

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


GCC 2032 | Phase 1 Feasibility Study of Strength Training with Androgen Deprivation and Proton Therapy for Intermediate and High Risk Prostate Cancer

Principal Investigator: Matthew Ferris, MD

Sites:

  • Maryland Proton Treatment Center

GCC 2048 | A Phase I Dose Escalation Study of Hypofractionated Accelerated Pelvic Nodal Radiotherapy Delivered With A Simultaneously Integrated Prostate Boost For Patients With Localized, Intermediate- And High-Risk Prostate Cancer

Principal Investigator: Mark Mishra, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


NRG GU002 | Phase II-III Trial Of Adjuvant Radiotherapy and Androgen Deprivation Following Radical Prostatectomy With or without Adjuvant Docetaxel

Principal Investigator: Mark Mishra, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Upper Chesapeake Health

Learn More: Find contact and eligibility information for this clinical trial.


NRG GU005 | Phase III IGRT and SBRT versus IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer

Principal Investigator: Young Kwok, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Baltimore Washington Medical Center
  • University of Maryland Shore Regional Health

Learn More: Find contact and eligibility information for this clinical trial.


NRG GU007 | Randomized Phase II Trial of Niraparib with Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High risk Prostate Cancer (With Initial Phase I)

Principal Investigator: Young Kwok, MD

Sites:

  • University of Maryland Medical Center
  • Central Maryland Radiation Oncology
  • University of Maryland Upper Chesapeake Health
  • University of Maryland Baltimore Washington Medical Center
  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


Pediatric Cancer Clinical Trials

Coordinator: Caitlin Eggleston | 410-328-7586


GCC 1669 | Pediatric Proton Consortium Registry: Registry for pediatric patients treated with proton RT

Principal Investigator: Young Kwok, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


Other Radiation Oncology Clinical Trials

Contact MPTC Research Office at 410-369-5226


GCC 1552 | PCG Registry | Evaluation Tracking Project: A Prospective Chart Review of Patients Treated with Radiation Therapy

Principal Investigator: Mark Mishra, MD

Sites:

  • Maryland Proton Treatment Center

Learn More: Find contact and eligibility information for this clinical trial.


GCC 19146 | Comparison and Verification of Radiation Planning for Pencil Beam Scanning Proton Therapy Using Single Energy and Dual Energy Computer Tomography Simulation Methods

Open for head and neck, brain and breast cancer.

Principal Investigator: Matthew Witek, MD, MS

Sites:

  • Maryland Proton Treatment Center

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